Journal article
Associations between Systemic and Cerebral Inflammation in an Ovine Model of Cardiopulmonary Bypass
K Elsaafien, JM Sloan, RG Evans, AD Cochrane, B Marino, PR McCall, SG Hood, ST Yao, WS Korim, SR Bailey, AH Jufar, RM Peiris, R Bellomo, LF Miles, CN May, YR Lankadeva
Anesthesia and Analgesia | LIPPINCOTT WILLIAMS & WILKINS | Published : 2023
Abstract
BACKGROUND: Intraoperative inflammation may contribute to postoperative neurocognitive disorders after cardiac surgery requiring cardiopulmonary bypass (CPB). However, the relative contributions of general anesthesia (GA), surgical site injury, and CPB are unclear. METHODS: In adult female sheep, we investigated (1) the temporal profile of proinflammatory and anti-inflammatory cytokines and (2) the extent of microglia activation across major cerebral cortical regions during GA and surgical trauma with and without CPB (N = 5/group). Sheep were studied while conscious, during GA and surgical trauma, with and without CPB. RESULTS: Plasma tumor necrosis factor-alpha (mean [95% confidence interva..
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Awarded by Australian Research Council
Funding Acknowledgements
This study was supported by project grants from the National Health and Medical Research Council of Australia (GNT1122455 and GNT1185777) and National Heart Foundation of Australia (VG104674). K.E. and J.M.S. are supported by the Australian Government Research Training Program Scholarships. S.T.Y. was supported by an Australian Research Council Future Fellowship (FT170100363). Y.R.L. was supported by a Future Leader Fellowship from the National Heart Foundation of Australia (NHF105666).